How the oldest enemy is still fought today.
« it’s going to be a very long war if for every division I have facing the enemy, I have one sick in hospital and another recovering from this dreadful disease. »
– General Douglas MacArthur, Commander of the United States Army Forces in the Far East, 1941.
Between the 17th and 22nd of May this year xRapid attended and presented at the ICMM World Congress on Military Medicine in Bali. Our CTO David Mendels spoke about the digital diagnostic tool he has developed and how it can be deployed in the field in order to offer fast and accurate malaria diagnosis without needing to access laboratory services.
When thinking about malaria, the relationship it has with the world’s military forces may not be your first thought. However, the conditions that military personnel often find themselves in when fighting in tropical climates are often hotbeds for tropical disease, and for the effectiveness of military operations this can be devastating.
« More person-days were lost among U.S. military personnel due to malaria than to bullets during every military campaign fought in malaria-endemic regions during the 20th century. »
The vast majority of people suffering from malaria suffer as a direct result of their immediate surroundings and situation. Communities that struggle with the disease often live and work in economically deprived, rural and tropical areas. Military operations fought in these areas risk the disease as the locals do, and in some cases are more at risk due to spending prolonged periods in temporary camps and not having built a relative immunity to the disease over years of indigenous living. This was particularly the case for the U.S Army during World War II campaigns in the Pacific and during the Vietnam War.
During WWII, the U.S military recorded over 500,000 cases of malaria whilst fighting against Japanese forces in the Pacific. During this period the Japanese controlled the global supply of quinine; the preferred anti-malarial at the time. This meant that the Americans were confined to using the sub-standard drug Atabrine, a treatment with severe side-affects. This development led scientists at WRAIR (Walter Reed Army Institute of Research) to launch the largest campaign to find new drugs for a disease the world had ever seen, and this led to the development of chloroquine.
Unfortunately the program was discontinued after the war ended, but history repeated itself two decades later during the Vietnam war. The Vietnam War saw an influx of hundreds of thousands of U.S soldiers into an area endemic with malaria that was resistant to the chloroquine developed by WRAIR. This spurred another round of research. However, it was Chinese scientists at the behest of the struggling Vietnamese army that developed artemisinin; the most common and effective anti-malarial still in use today.
Both of these wars were instrumental in the development of current malaria treatments and research into new treatments, diagnostic techniques and vaccines continues at WRAIR and other military research institutes throughout the world. However, despite considerable advances from inside and outside of military communities malaria does remain a serious issue for operations. Malaria is still a big risk for military personnel in the field due to the fact the parasite is so complex and adaptable. Developing new treatments and chemoprophylaxis requires extensive research and malaria parasites are constantly developing resistance to treatments.
The use of some chemoprophylaxis by militaries in order to prevent infection is a complicated business. Providing large amounts of chemoprophylactics for operations is expensive and fraught with logistical difficulty. Finding the optimum amount of a prophylactic drug to introduce into the bloodstream in order to provide protection from malaria balanced with minimal side effects is difficult, but extremely important. As with Atabrine, many modern prophylactic drugs for malaria can have serious side effects. The most notable of these, after being in the news in recent years, is mefloquine. The most documented adverse effect of mefloquine is a striking neuropsychiatric problem. A small amount of soldiers in Afghanistan and Iraq taking mefloquine were implicated in a cluster of grisly murder-suicides between 2002 and 2004 and studies from the Irish military showed that soldiers taking mefloquine were 3-5 times more at risk of being a danger to themselves.
Added to the growing threat of drug resistance, these problems have meant that there is a growing call for an effective malaria vaccine from both military and civilian circles. The final goal of such a vaccine is of course malaria eradication, and military contributions towards this goal have been highly significant.
Two of the most important criteria for elimination as specified by the Military Malaria Research Program at WRAIR are highly effective vaccines and improved diagnostic methods. There has been breakthroughs in these areas; a recent study for an effective child malaria vaccine has yielded positive results, although scientists are wary that the implications for global public health are currently intangible due to an increased susceptibility to malaria if the vaccine is not topped up with a booster shot in a timely fashion.
Problems with malaria diagnosis in elimination strategies, and for military operations and civilian populations more generally, are often to do with accessibility and accuracy. Malaria is a disease that can be treated effectively if it is caught early, and for military operations this means in the field. Sufficient laboratory equipment and expertise is hard to access, and RDTs (rapid diagnostic tests) alone are often not accurate enough.
This brings us back to the World Congress of Military Medicine in Bali, and why xRapid decided to exhibit there. xRapid is very portable and can be deployed to field hospitals during military operations or humanitarian efforts. It also requires less expertise to generate an accurate set of results than traditional optical microscopy. An accurate diagnosis with a parasite count figure included can inform treatment to the extent where medical professionals can prescribe exactly the right amount of anti-malarials, stopping over-treatment and slowing the rise of drug resistance. This makes xRapid a valuable weapon for militaries around the world.
The contribution that military communities have made towards malaria research over the past century has been hugely significant. Institutes such as WRAIR have been instrumental in developing some of the most widely used anti-malaria strategies in the world, many of which are still in use today. It is sometimes the case that war has makes these advances a necessity; the Vietnam War was arguably won and lost because of malaria. However, the culture of combating tropical disease in military organisations around the world has given way to some astonishing breakthroughs. Whilst there are always issues with new drugs or vaccines, these breakthroughs have saved hundreds of thousands lives.